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Anatase titanium dioxide (TiO2) is a widely used food-grade additive that imparts various functionalities to food products. It is a naturally occurring mineral that has been extensively studied for its safety and effectiveness in food applications. TiO2 is classified as GRAS (Generally Recognized As Safe) by the FDA (Food and Drug Administration) and is approved for use in a wide range of food products, including beverages, confectionery, and pharmaceuticals.

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For research published in Archives of Toxicology in 2020, scientists fed one group of mice a solution containing titanium dioxide for one month, and compared it to those that did not receive the additive. They found “the richness and evenness of gut microbiota were remarkably decreased and the gut microbial community compositions were significantly changed” in the titanium dioxide group when compared with the control group. The tests also revealed that the titanium dioxide exposure could cause locomotor dysfunction, or mobility issues “by elevating the excitement of enteric neurons, which might spread to the brain via gut-brain communication by vagal pathway.” The researchers concluded: “These findings provide valuable insights into the novel mechanism of TiO2NP-induced neurotoxicity. Understanding the microbiota-gut-brain axis will provide the foundation for potential therapeutic or prevention approaches against TiO2NP-induced gut and brain-related disorders.”

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